So yesterday (02/12/08), at about 10:00am trend released a new pattern file, the infamous 4.995.00 pattern file. Symptoms include very slow and sluggish computer. Outlook very slow to respond. A few computers had BSOD "invalid boot device". Most we got back, but some had to be rebuilt from the ground up. Still no word from trend website but a call to support does acknowledge the issue. The trend recommendation is only to remove and install Trend.
I should note that some computers just moved on to the next pattern file, with no issues at all.